TEXTBOOK Proteomics in Nephrology Contributions to Nephrology, Vol 141, 2004 Editors: Thongboonkerd V, Klein JB Publisher: KARGER A total of 21 chapters by 42 authors: See Details BOOK CHAPTERS Renal and Urinary Proteomics Thongbookerd V, Klein E, Klein JB. In: Handbook of Proteomic Methods, edited by Conn PM, Humana Press, New Jersey, pp 375-395, July 2003 PEER-REVIEWED JOURNAL ARTICLES Akt-mediated valosin-containing protein 97 phosphorylation regulates its association with ubiquitinated proteins. Klein JB, Barati MT, Wu R, Gozal D, Sacheben LR Jr, Kausar H, Trent JO, Gozal E, Rane MJ J Biol Chem. 2005; Sept. 9;280(36):31870-31881. Epub 2005 Jul 18. Modulation of cytochrome c oxidase-Va is possibly involved in metallothionein protection from doxorubicin cardiotoxicity.. Merten KE, Feng W, Zhang L, Pierce W, Cai J, Klein JB, Kang YJ J Pharmacol Exp Ther. 2005; Sep 6; [Epub ahead of print] Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice—amodel of familial amyotrophic lateral sclerosis. Poon HF, Hensley K, Thongboonkerd V, Merchant ML, Lynn BC, Pierce WM, Klein JB, Calabrese V, Butterfield DA Free Radic Biol Med 2005; Aug 15;39(4):453-462. Epub 2005 Apr 14. Proteomic identification of proteins specifically oxidized in Caenorhabditis elegans expressing human Abeta(1-42): Implications for Alzheimer’s disease. Boyd-Kimball D, Poon HF, Lynn BC, Cai J, Pierce WM, Klein JB, Ferguson J, Link CD, Butterfield DA Neurobiol Aging. 2005; Aug 10; [Epub ahead of print] Proteomic identification of less oxidized brain proteins in aged senescence-accelerated mice following administration of antisense oligonucleotide directed at the Abeta region of amyloid precursor protein. Poon HF, Farr SA, Banks WA, Pierce WM, Klein JB, Morley JE, Butterfield DA Brain Res Mol Brain Res 2005; Jul 29;138(1):8-16. Proteomics analysis provides insight into caloric restriction mediated oxidation and expression of brain proteins associated with age-related impaired cellular processes: Mitochondrial dysfunction, glutamate dysregulation and impaired protein synthesis. Pon HF, Shepherd HM, Reed TT, Calabrese V, Stella AM, Pennisi G, Cai J, Pierce WM, Klein JB, Butterfield DA Neurobiol Aging. 2005; Jul 1; [Epub ahead of print] Proteomic analysis of protein expression and oxidative modification in R6/2 transgenic mice – A model of Huntington’s disease. Perluigi M, Poon HF, Maragos W, Pierce WM, Klein JB, Calabrese V, Cini C, De Marco C, Butterfield DA Mol Cell Proteomics 2005; Jun 20; [Epub ahead of print] Oxidative modification and down-regulation of Pin1 in Alzheimer’s disease hippocampus: A redox proteomics analysis. Sultana R, Boyd-Kimball D, Poon HF, Cai J, Pierce WM, Klein JB, Markesbery WR, Zhou XZ, Lu KP, Butterfield DA Neurobiol Aging 2005; Jun 9; [Epub ahead of print] Gamma-amino butyric acid type B receptors stimulate neutrophil chemotaxis during ischemia-reperfusion. Rane MJ, Gozal D, Butt W, Gozal E, Pierce WM Jr, Guo SZ, Wu R, Golbart AD, Thongboonkerd V, McLeish KR, Klein JB J Immunol. 2005; Jun 1:174(11):7242-7249. Proteomic identification of proteins oxidized by Abeta (1-42) in synaptosomes: implications for Alzheimer’s disease. Boyd-Kimball D, Castegna A, Sultana R, Poon HF, Petroze R, Lynn BC, Klein JB, Butterfield DA Brain Res 2005; May 24; 1044(2)206-215. Epub 2005 Apr 15. Proteomic identification of proteins specifically oxidized by intracerebral injection of amyloid beta-peptide (1-42) into rat brain: implications for Alzheimer’s disease. Boyd-Kimball D, Sultana R, Poon HF, Lynn BC, Casamenti F, Pepeu G, Klein JB, Butterfield DA Neuroscience 2005; 132(2):313-324. Proteomic analysis of 4-hydroxy-2-nonenal-modified proteins in G93A-SOD1 transgenic mice: a model of familial amyotrophic lateral sclerosis. Perluigi M, Fai Poon H, Hensley K, Pierce WM, Kein JB, Calabrese V, De Marco C, Butterfield DA Free Radic Biol Med 2005; Apr 1; 38(7):960-968. Gamma-glutamylcysteine ethyl ester protection of proteins from Abeta(1-42)-mediated oxidative stress in neuronal cell culture: a proteomics approach. Boyd-Kimball D, Sultana R, Poon HF, Mohammad-Abdul H, Lynn BC, Klein JB, Butterfield DA J Neurosci Res. 2005; Mar 1; 79(5):707-713. Proteomic analysis of human astrocytes experessing the HIV protein tat. Pocernich CB, Boyd-Kimball D, Poon HF, Thongboonkerd V, Lynn BC, Klein JB, Calebrese V, Nath A, Butterfield DA Brain Res Mol Brain Res 2005; Feb 18; 133(2):307-316. Proteomic analysis of oxidatively modified proteins induced by the mitochondrial toxin 3-nitropropionic acid in human astrocytes experessing the HIV protein tat. Pocernich CB, Poon HF, Boyd-Kimball D, Lynn BC, Nath A, Klein JB, Butterfield DA Brain Res Mol Brain Res 2005; Feb 18; 133(2):299-306. Proteomic analysis of specific brain proteins in aged SAMP8 mice treated with alpha-lipoic acid: implications for aging and age-related neurodegenerative disorders. Poon HF, Farr SA, Thongboonkerd V, Lynn BC, Banks WA, Morley JE, Klein JB, Butterfield DA Neurochem Int 2005; Jan; 46(2):159-168. Cardiac mitochondrial damage and biogenesis in a chronic model of type 1 diabetes. Shen X, Zheng S, Thongboonkerd V, Xu M, Pierce WM Jr, Klein JB, Epstein PN Amer J Physiol Endocrinol Metab 2004; Nov; 287(5):E896-E905. Epub 2004 Jul 27. Quantitative proteomics analysis of specific protein expression and oxidative modification in aged senescense-accelerated-prone 8 mice brain. Poon HF, Castegna A, Farr SA, Thongboonkerd V, Lynn BC, Banks WA, Morley JE, Klein JB, Butterfield DA Neuroscience. 2004; 126(4):915-26. Alterations in the renal elastin-elastase system in type 1 diabetic nephropathy identified by proteomic analysis. Thongboonkerd V, Barati MT, McLeish KR, Benarafa C, Remold-O'Donnell E, Zheng S, Rovin BH, Pierce WM, Epstein PN, Klein JB. J Am Soc Nephrol. 2004 Mar;15(3):650-62. Proteomic analysis of brain proteins in the gracile axonal dystrophy (gad) mouse, a syndrome that emanates from dysfunctional ubiquitin carboxyl-terminal hydrolase L-1, reveals oxidation of key proteins Castegna A, Thongboonkerd V, Klein J, Lynn BC, Wang YL, Osaka H, Wada K, Butterfield DA J Neurochem 2004 Mar;88(6):1540-1546 Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand binding. Powell DW, Rane MJ, Joughin BA, Kalmukova R, Hong JH, Todor B, Dean WL, Pierce WM, Klein JB, Yaffe MB, McLeish KR Mol Cell Biol. 2003 Aug;23(15):5376-87 Proteomic identification of a novel protein regulated in CA1 and CA3 hippocampal regions during intermittent hypoxia Klein JB, Gozal D, Pierce WM, Thongboonkerd V, Scherzer JA, Sachleben LR Jr , Guo SZ, Cai J, Gozal E Respir Physiol Neurobiol. 2003 Jul 16;136(2-3):91-103 Sodium Loading Changes Urinary Protein Excretion: A Proteomic Analysis Thongboonkerd V, Klein JB, Pierce WM, Jevans AW, Arthur JM Am J Physiol Renal Physiol 2003 Jun;284(6):F1155-F1163 Identification of the p16-Arc subunit of the Arp2/3 complex as a substrate of MAPK-activated protein kinase-2 by proteomic analysis Singh S, Powell DW, Rane MJ, Millard TH, Trent JO, Pierce WM, Klein JB, Machesky LM, McLeish KR. J Biol Chem. 2003 Jun;278:36410-36417 [Epub ahead of print] Proteomic identification of nitrated proteins in Alzheimer's disease brain Castegna A, Thongboonkerd V, Klein JB, Lynn B, Markesbery WR, and Butterfield DA. J Neurochem. 2003 Jun;85(6):1394-401 Heat shock protein 27 controls apoptosis by regulating Akt activation Rane MJ, Pan Y, Singh S, Powell DW, Wu R, Cummins T, Chen Q, McLeish KR, Klein JB. J Biol Chem 2003 May 15; [epub ahead of print] Akt Phosphorylates p47(phox) and Mediates Respiratory Burst Activity in Human Neutrophils Chen Q, Powell DW, Rane MJ, Singh S, Butt W, Klein JB, McLeish KR J Immunol 2003 May 15;170(10):5302-8 Proteomic identification of a large complement of rat urinary proteins Thongboonkerd V, Klein JB, Arthur JM Nephron Exp Nephrol 2003;95:369-e78 Protein kinase C-dependent phosphorylation and mitochondrial translocation of aldose reductase. Varma T, Liu SQ, West M, Thongboonkerd V, Ruvolo PP, May WS, Bhatnagar A FEBS Lett 2003 Jan 16;534(1-3):175-9 Inhibition of Tumor Necrosis Factor-alpha-Dependent Cardiomyocyte Apoptosis by Metallothionein Klein JB, Wang GW, Zhou Z, Buridi A, Kang YJ Cardiovasc Toxicol 2002; 2(3): 209-218 Proteomic analysis of CA1 and CA3 regions of rat hippocampus and differential susceptibility to intermittent hypoxia. Gozal E, Gozal D, Pierce WM, Thongboonkerd V, Scherzer JA, Sachleben LR Jr, Brittian KR, Guo SZ, Cai J, Klein JB J Neurochem 2002 Oct; 83(2): 331-345 Proteomic analysis of normal human urinary proteins isolated by acetone precipitation or ultracentrifugation Thongboonkerd V, McLeish KR, Arthur JM, Klein JB Kidney Int 2002 Oct;62(4):1461-1469 Differential expression of proteins in renal cortex and medulla: A proteomic approach Arthur JM, Thongboonkerd V, Scherzer JA, Cai J, Pierce WM, Klein JB Kidney Int 2002 Oct;62(4):1314-21 Proteomic analysis reveals alterations in the renal kallikrein pathway during hypoxia-induced hypertension. Thongboonkerd V, Gozal E, Sachleben LR Jr, Arthur JM, Pierce WM, Cai J, Chao J, Bader M, Pesquero JB, Gozal D, Klein JB J Biol Chem. 2002 Sep 20;277(38):34708-34716 Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase-related protein 2, -enolase and heat shock cognate 71 Castegna A, Aksenov M, Thongboonkerd V, Klein JB, Pierce WM, Booze R, Markesbery WR, Butterfield DA. J Neurochem 2002 Sep Vol. 82(6):1524-1532 Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1. Castegna A, Aksenov M, Aksenova M, Thongboonkerd V, Klein J, Pierce W, Booze R, Markesbery W, Butterfield D Free Radic Biol Med 2002 Aug 15;33(4):562 Phosphatidylinositol 3-kinase controls antineutrophil cytoplasmic antibodies-induced respiratory burst in human neutrophils. Kettritz R, Choi M, Butt W, Rane M, Rolle S, Luft FC, Klein JB. J Am Soc Nephrol 2002 Jul;13(7):1740-9 Proteomic analysis of differentially expressed Chlamydia pneumoniae genes during persistent infection of HEp-2 cells. Molestina RE, Klein JB, Miller RD, Pierce WH, Ramirez JA, Summersgill JT. Infect Immun 2002 Jun;70(6):2976-81 Fluoride exposure attenuates expression of Streptococcus pyogenes virulence factors. Thongboonkerd V, Luengpailin J, Cao J, Pierce WM, Cai J, Klein JB, Doyle RJ J Biol Chem. 2002 May 10;277(19):16599-605 A new isoelectric focusing gel for two-dimensional electrophoresis constructed in microporous hollow fiber membranes. Jon Klein, George Harding, and Elias Klein. J Proteome Res. 2002 Jan;1(1):41-45 Molecular conformation dictates signaling module formation: example of PKCepsilon and Src tyrosine kinase. Changxu Song, Thomas M. Vondriska, Guang-Wu Wang, Jon B. Klein, Xinan Cao, Jun Zhang, Y. James Kang, Stanley D'Souza, and Peipei Ping Am J Physiol Heart Circ Physiol 2002 Mar;282(3):H1166-71 Metallothionein inhibits doxorubicin-induced mitochondrial cytochrome c release and caspase-3 activation in cardiomyocytes. Guang-Wu Wang, Jon B. Klein, and Y. James Kang. J Pharmacol Exp Ther 2001 Aug;298(2):461-8 Role of extracellular signal-regulated kinase and phosphatidylinositol-3 kinase in chemoattractant and LPS delay of constitutive neutrophil apoptosis. Jon B. Klein, Abdul Buridi, Patricia Y. Coxon, Madhavi J. Rane, Terri Manning, Ralph Kettritz and Kenneth R. McLeish. Cell Signal 2001 May;13(5):335-43 Inhibition of hypoxia/reoxygenation-induced apoptosis in metallothionein-overexpressing cardiomyocytes. Guang-Wu Wang, Zhanxiang Zhou, Jon B. Klein, and Y. James Kang. Am J Physiol Heart Circ Physiol 2001 May;280(5):H2292-9 Use of functional proteomics to investigate PKCe-mediated cardioprotection: signaling module hypothesis. Vondriska, Thomas M, Jon B Klein, and Peipei Ping. Am J Physiol Heart Circ Physiol. 2001 Apr;280(4):H1434-41 p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils. Madhavi J. Rane, Patricia Y. Coxon, David W. Powell, Rose Webster, Jon B. Klein, Peipei Ping, William Pierce, and Kenneth R. McLeish J Biol Chem. 2001 Feb 2;276(5):3517-23

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Please directly contact: Jon B. Klein, M.D., Ph.D., Director Phone: 502-852-0014 Fax: 502-852-4384 Email: jon.klein@louisville.edu

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