This database was developed with the support of grant funds from the NHLBI "Proteomic Analysis of Hippocampal Hypoxic Vulnerability" (RO1-HL66358) as part of the request for applications "Oxygen Sensing During Intermittent Hypoxia" (RFA HL-00-004).
The purpose of this initiative is to improve our understanding of how intermittent hypoxia contributes to the pathophysiology of cardiopulmonary, vascular, hematological, and sleep disorders. Specific objectives are to determine the basic molecular and genomic mechanisms involved in cellular responses to brief intermittent hypoxic episodes including mechanisms responsible for the detection and signaling of oxygen level changes, and the mechanisms that mediate adaptive changes in metabolism, oxygen sensing, and gene expression.
Principal Investigator:
Jon Klein, M.D., Ph.D.
Co-Investigators:
Evelyne Gozal, Ph.D., William M. Pierce, Ph.D., and David Gozal, M.D.
